First-Episode Psychosis, Early Intervention, and Outcome: What Have We Learned?

First-episode psychosis, early intervention, and outcome: what have we learned?

OBJECTIVE There has been increased interest in the potential of early intervention to positively influence outcome in first-episode psychosis (FEP) and, consequently, to influence mental health policy and practice. This study's objective was to examine the concept of early intervention and the evidence that currently exists to support such a shift in the delivery of care. METHOD We examined t...

What have we learned from research into first-episode psychosis?

A new stage in the conceptualisation of schizophrenia has begun. It is defined by greater optimism for the future for those who suffer from this disease, a future that is less damaging and fatalistic as the one postulated up until very recently. Today psychiatry stands in the middle of a crossroads. Research has achieved great advances and the time to consolidate an important qualitative change...

Early intervention for first episode psychosis.

Pathophysiology of Ischemia/Reperfusion-induced Myocardial Injury: What We Have Learned From Preconditioning and Postconditioning?

Organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. The pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. Protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. In this review, we discuss basic mechan...

What Have We Learned?

FIVE YEARS AFTER THE INSTITUTE of Medicine (IOM) reported that as many as 98 000 people die annually as the result of medical errors and called for a national effort to make health care safe, it is time to assess our progress. Is health care safer now? And, if not, why not? The IOM’s report, To Err Is Human: Building a Safer Health System, galvanized a dramatically expanded level of conversatio...